Seek urgent medical attention (contact 111 or attend A&E) if you experience: Severe or persistent diarrhoea lasting more than 48 hours, particularly if accompanied by fever, blood in stools, or severe abdominal pain Signs of dehydration : extreme thirst, dizziness or lightheadedness, significantly reduced urine output, dark-coloured urine, confusion, or rapid heartbeat Severe abdominal pain that is different from your usual IBS symptoms, especially if constant or worsening Persistent vomiting preventing you from keeping down fluids or medications Signs of pancreatitis : severe upper abdominal pain radiating to the back, nausea, and vomiting (a rare but serious side effect of GLP-1 agonists) Allergic reactions : rash, itching, swelling, severe dizziness, or difficulty breathing Contact your GP or prescribing clinician within 1-2 days if you experience: Moderate diarrhoea affecting your daily activities or quality of life Persistent nausea or reduced appetite preventing adequate nutrition Worsening of IBS symptoms despite taking linaclotide Inadequate weight loss response to Wegovy after 3-6 months New or worsening abdominal symptoms that concern you Difficulty tolerating either medication due to side effects Questions about medication timing, dosing, or interactions with other medicines Routine follow-up appointments should be maintained as scheduled by your healthcare provider, typically every 3-6 months once treatment is established
[1] On 8 January 1948, the Nationalist Chinese government sent a memorandum to the British Ambassador, stating "The Ministry of Foreign Affairs now formally declare to the British Embassy that, in accordance with the provisions of the said Convention, the Chinese Government enjoys jurisdiction over the City of Kowloon and that they have no intention whatsoever of renouncing this jurisdiction." [7] The British Foreign Office, on 4 February 1948, considered a variety of solutions (including turning the site into a Nationalist Chinese Consulate-General), and ultimately recommended that the British "accept the principle of Chinese jurisdiction over Kowloon Walled City but the Chinese agree not to attempt to exercise that jurisdiction in practice." [7] Additionally, the British Foreign Office said that "A public garden controlled by the municipal authorities of Kowloon Leased territory offers such a solution and so would a Chinese consular compound, if the Chinese could first be induced to agree in principle to the appointment of a Consul General." [7] In January 1950, a fire broke out that destroyed over 2,500 huts, home to nearly 3,500 families and 17,000 total people
doi:10.1177/15563316251355551 Gwyer D, Wragg NM, Wilson SL
Or, double-check the instructions and make sure you werent doing something wrong
The primary indication for therapy is paramountpatients using these medications for type 2 diabetes management typically require long-term treatment as part of comprehensive disease management, whereas those using GLP-1 agents solely for weight management may have more flexibility depending on their response and circumstances
Arch Dermatol 128:934940 Carney JA, Gordon H, Carpenter PC et al (1985) The complex of myxomas, spotty pigmentation, and endocrine overactivity
